An overview on natural farnesyltransferase inhibitors for efficient cancer therapy
نویسندگان
چکیده
منابع مشابه
Cancer Therapy: An Overview
Volume 6(1) 1000e130 J Cancer Sci Ther ISSN: 1948-5956 JCST, an open access journal Cancer has existed probably since the dawn of civilization; however, it came into prominence during 19th century. There could be many reasons because of which cancer remained out of public attention. Age is one of the strongest causal factors in case of most of the cancers, and symptoms of cancer manifests or be...
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This article presents an overview of preclinical studies and clinical trials of a number of independently derived farnesyltransferase inhibitors (FTIs). Potential targets and biological modes of action of FTIs are discussed, and the results of clinical trials are summarized. The significant efficacy of FTIs as single or combined agents in preclinical studies stands in contrast with only moderat...
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Farnesyltransferase inhibitors (FTIs) are small-molecule inhibitors that selectively inhibit farnesylation of a number of intracellular substrate proteins such as Ras. Preclinical work has revealed their ability to effectively inhibit tumor growth across a wide range of malignant phenotypes. Many hematologic malignancies appear to be reasonable disease targets, in that they express relevant bio...
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Mutant ras oncogenes and alterations in the mitogenic signaling pathways that they regulate are associated with a wide variety of solid tumors and leukemias for which existing chemotherapeutics have limited utility. Of the possible approaches to inhibit Ras function, much attention has focused on a posttranslational modification, farnesylation, which is required for the subcellular localization...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2020
ISSN: 1475-6366,1475-6374
DOI: 10.1080/14756366.2020.1732366